Systemic Diseases.
New view on etiology and pathogenesis
The term rheumatism, "the flow of liquid" in Greek, was coined by Dr. Galen, a Roman physician, approximately 1800 years ago. This seemingly unsuitable term, today, had originated from a prevalent then belief that four types of fluids circulate in the human body: blood, mucus, bile and black bile, which are sustained in a perfect ratio, and that all human diseases arise from disturbances in their proportion and interaction. At the time, the society’s elite were commonly suffering from gout (podagra) that mainly affected the big toe. Dr. Galen was a court physician and he frequently dealt with this disease. Proceeding from the representations accepted in the medical world at the time, by using the term rheumatism, Dr. Galen had characterized and described symptoms of concretely podagra. Rheumatism with its characteristic symptoms as recognized by modern medicine could not have existed at the times of Dr. Galen because biological basis for the occurrence of systemic pathologies in the human body were nonexistent. At that time, the human body lacked the necessary features and biological basis for the appearance of systemic diseases.
Besides, if rheumatism as the systemic disease had appeared 1800 years ago, it is logical to assume that all other disease of this group such as glomerulonephritis, systemic scleroderma, dermatomyositis, systemic lupus erythematosus, periarteritis nodosa, and others would have immediately followed it instead of emerging only nearly two millennia later.
Humanity returned back to using this term only in 1835 when for the first time, Dr. Bouillaud, a French physician, described the symptom complex of a completely new disease, a disease that was fundamentally different from what was described and treated by Dr. Galen. Dr. Bouillaud called the newly brought to light disease in honor of Dr. Galen as rheumatism. This is how a new era unfolded in the history of humanity and medicine, an era of the systemic pathologies that would rule over all the human diseases during the coming centuries.
The pathocomplex process as the origin of rheumatism
During the last centuries, leukocyte defense mechanisms were subjected to change. Gradually, with the advent of high-molecular-weight antigens, body defense functions passed over to B-lymphocytes, primarily and protein or humoral immunity emerged to the first place. Immunoglobulin protein molecules, which previously floated freely through the bloodstream, now mostly remained fixated to the surface of B-lymphocytes and hunted for foreign pathogenic agents whilst circulating in the blood flow in such form. If until that time, antigen destruction was carried out mainly through phagocytosis, with appearance of humoral immunity, the process of defense shifted to the formation of immune complexes that are specifically directed at the destruction of large-molecular-weight protein molecules. Following antigen destruction, these immune complexes now had to be disassembled wherein B-lymphocyte cells were released one by one to continue performing their further defensive function. The lymphocytes are released from immune complexes when the number of B-lymphocytes exceeds the number of antigens. This means that after being released from an immune complex, B-lymphocyte cells must have time to circulate in the circulatory system independently. If the number of antigens, especially those of protein nature, exceeds the number of B-lymphocytes, these cells cannot circulate independently after they are disassociated since they are compelled to immediately attack another antigen by forming a new complex. Consequently, B-lymphocytes, as the primary elements of organism’s defense potential, are constantly confined in complexes and never get to circulate in the bloodstream in their free form. This continual process exerts excessive load on immune system.
The second and the primary cause of B-lymphocytes retention in immune complexes, even without taking into account the excessive number of antigens in today’s world, is a deficiency of factors required for the disassociation of these complexes and in fact, this is what creates the pathological basis for the development of all systemic diseases.
When any living creature is subjected to changes in environmental conditions, its body undergoes corresponding transformations. This is a natural adaptive response of every organism. Mandkind’s sharp alienation from its natural and habitual living conditions played a fateful role in the reorganization of his biology. Drastic biological, evolutionary and adaptive changes have unavoidably occurred following human sharp turn towards urbanization, as required by nature, leaving a permanent mark on all of our further existence. A consequence of these changes are the degenerative processes in organs charged with synthesizing substances required for the disbandment of immune complexes and therefore, the release of B-lymphocytes. For the first time during the existence of biologic beings appear pathological immune complexes (pathocomplexes) that lost their physiological capability to disband due to a shortage of certain biochemical substances. While circulating in the bloodstream, the non-disbanded immune complexes attract other plasma elements, including erythrocytes, thrombocytes, as well as leukocytes and protein molecules, thus forming huge (in terms of biology) aggregates. One after another, large aggregates floating in the blood flow clog up the blood vessels and disseminately sediment on the serous membranes of various organs, triggering inflammation and hence, a completely new symptom complex of systemic pathologies. Humanity encounters a new phenomenon in medicine called the pathocomplex process.
On the basis of emerged accumulating conditions, in 1835, a French physician, Dr. Bouillaud, for the first time in the history of medicine discovers a disease that was never encountered before, a disease that had no similarity to the disease that was once described by Dr. Galen. What Dr. Bouillaud described already manifested a clinical symptom complex of a new group of diseases that had nothing in common with the condition once called as rheumatism by Dr. Galen. Thus, Dr. Bouillaud laid the foundation for disclosing the subsequent diseases that were identified one by one up to the 1920s.
In 1936, a short time after Dr. Bouillaud had described the symptoms of rheumatism, Dr. Bright detected glomerulonephritis and in 1847, Dr. Gintrak detected systemic scleroderma. Then in 1891, Dr. Unverricht and Dr. Wagner discovered dermatomyositis. In the period of 1894 to 1903, Dr. Crocker and Dr. Williams described systemic lupus erythematosus and in 1926, periarteritis nodosa was first detected by Dr. Gruber. As it is seem, all diseases of this group were detected after 1835.
It is only now, 190 years since the outbreak of rheumatism, that the basis for the emergence of this disease is discovered for the first time in the human history and described by us on the molecular level. Along with defining the detail mechanisms of systemic pathologies’ occurrence (including rheumatism), for the first time in the history of medicine we can promote a radical method for completely curing them, a method that has been successfully applied for the treatment of all diseases in this group, thus proving its validity in practice.
The role of monocytes in the formation of clinical manifestations
of the pathocomplex process
During pre-natal development and the first years of life, monocytes, being the most mysterious human blood leukocytes, penetrate into body tissues and fixate there forever. The cells that in medical sciences and especially in histology are known as tissue macrophages are the same mysterious monocytes, fixated unto various tissues of our body. Virtually all our blood leukocytes have surface receptors (CDs – clusters of differentiation), which are also identical for other formed elements of the plasma. Some of B-cell receptors have structural similarities with receptors that are located on the surface of tissue macrophages. For this reason, the pathocomplexes that are circulating in the bloodstream can be attracted to these tissue macrophages that look to capture and fixate foreign substances in order to destroy them.
Every individual has his own specific map of macrophage disposition in his body depending on the script of his fetal development and first years of life. The role of tissue macrophages in the organism of the patient with pathocomplex process consists in formation of the symptom complex of the certain systemic disease. The primary areas of pathocomplex sedimentation are determined by the distinct distribution of macrophages, which in turn, determines which systemic disease’s symptom complex will predominate. Therefore, despite the fact that theoretically all diseases of this group are described as separate nosological forms, it is not possible to observe an isolated picture of a single systemic disease in practice.
When tissue macrophages are mostly accumulated in the serous membranes of joints and joint sets, pathocomplexes primarily settle on these organs and trigger symptoms characteristic to rheumatism and rheumatoid arthritis. Predominant accumulation of macrophages in the skin and muscles leads to the sedimentation of pathocomplexes on these tissues, which triggers a systemic disease with a predominant symptom complex of either dermatomyositis or scleroderma, respectably. By the same principle arise glomerulonephritis (when pathocomplexes are mainly adsorbed by the kidneys), periarteritis nodosa (when pathocomplexes are mainly adsorbed by the blood vessels), multiple sclerosis, Parkinsonism, chorea (when pathocomplexes are mainly adsorbed by the brain tissue), etc. One of the serious diseases characterized by having dispensed symptoms of all systemic pathologies, without a tendency to affect concrete organs is systemic lupus erythematosus.
Despite relatively selective lesions of the body that allow identifying the most approximate diagnosis of a specific systemic disease, vague boundaries are characteristic for other diseases of this group as well. This means that despite the fact that all pathocomplex-induced diseases are manifestations of the same process; the map of tissue macrophage distribution is the determining factor in the proliferation of the symptoms of a particular systemic pathology. Exactly these macrophages define the damage area at systemic diseases.
Why is rheumatism accompanied by angina?
All systemic pathologies are accompanied by a partial or complete immunodeficiency. What is the source of this immune deficiency?
Leucocytes, especially lymphocytes are the primary defense factors of human immune system. During an immune reaction to antigens that have penetrated the body, B-lymphocytes are forced to join them (antigens), thereby forming immune complexes. For the time they are attached to the antigen to destroy it and until the immune complex is disbanded, B-lymphocytes are temporarily neutralized.
The whole complex process that takes place with B-lymphocytes tends to resemble a situation that arises when two policemen handcuff themselves a criminal and thus become practically neutralized, unable to perform further defense actions until they are released from the handcuffs. Similarly, the В-lymphocytes form immune complexes by attaching to antigens and are released from these complexes only after their disbandment. Being locked in the network of pathocomplexes, В-lymphocytes lose their protective abilities forever.
A decrease or a termination in synthesis of substances required for the disbandment of immune complexes, partially or completely impedes the process of B-lymphocytes release. As a result, a huge number of B-lymphocytes remains locked in the networks of pathocomplexes in a neutralized state, deprived of the opportunity to perform their usual protective function. Based on the degree of pathocomplex formation, immunodeficiency manifests in either a partial form, as in systemic diseases such as rheumatism, systemic lupus erythematosus, systemic scleroderma or a complete form such as in Acquired Immunodeficiency Syndrome (AIDS).
As a consequence of an immune deficiency induced by the pathocomplex process, different microorganisms can penetrate through the biological gates of the body (respiratory tract and urogenital system) and cause inflammation of these organs. Frequent angina, pneumonia, bronchitis, pyelonephritis, and even sepsis, which leads to endocarditis and myocarditis, are merely consequences of immune deficiency, the presence of which is characteristic to all pathocomplex diseases.
Until recently and in most cases to this day, modern medicine practitioners believe that concretely Streptococcus, traces of which are detected in the blood of patients suffering from rheumatism, is the etiological factor of rheumatism occurrence. Frequently in medicine, however, as well as in other areas of science, everywhere widespread rectilinear observations, is deceptive conducting to the primitive conclusion. What was found, what was seen, it has been accused. If streptococcus is found, then this is what triggers rheumatism. This is how the same pervasive and silly mistake as with cholesterol and triglycerides in cardiovascular diseases, sugar in diabetes and HIV in AIDS comes about. This is exactly why long-acting antibiotics such as bicillin are currently used for treating rheumatism and why temporary positive effects obtained are considered as the confirming factors for the proposed "theory".
The introduction of antibiotics and their relatively successful empirical use in treating systemic diseases gave way to the appearance, and subsequent consolidation of the "theory" of bacterially induced rheumatism. The temporary success of antibiotic therapy turned the search for true sources of this group of pathologies half a century back. Basically it is related with difficulties of destruction of any taken roots, unjustified, but so widely accepted "theory".
Despite the fact that depending on which organs are primarily affected in systemic pathologies every patient will have a wide range of individual symptoms peculiar to him. However, as regards the presence of immunodeficiency, all illnesses of this group are identical. Immune deficiency of varying degrees occurs in all pathocomplex induced diseases and it must be etiologically eliminated in parallel with the treatment of other symptoms. Antibiotics are not capable to eliminate the reason of occurrence of infectious diseases in system pathologies, and only suppress them, as already consequences of presence of immunodeficiency.
As proved empirically till now, the unity of systemic pathologies’ origin can once again be confirmed scientifically and analytically with the birth of the pathocomplex process theory, as well as based on the similarity in treatment assigned by different specialists for all the different pathologies of this group. Ascertaining the truth that all systemic pathologies arise from a single origin is the key to defeating the diseases that have been turning the lives of 350 million people into every minute suffering.
Treatment of systemic diseases
Streptococcus, or the pathocomplex process? What is the source of systemic diseases, after all? The tactic and effectiveness of the treatment of all collagenosis depends upon the resolution to this question. For half a century, streptococcus dominated amongst "theories" explaining the etiology of diseases of this group and nonetheless, rheumatism is far from being over.
According to the statistics of the World Health Organization for 2000, 350 million people in the world suffer from systemic pathologies and all of them without exception are deprived of an effective treatment. Besides non-steroidal anti-inflammatory drugs, corticosteroids and cytotoxic drugs that yield greater side effects than treatment, current medicine has no other means and methods at disposal. By receiving such treatment out of despair, no one ever recover from these diseases. Sooner or later, 99% of patients become simply disabled. Such therapy is directed at relatively relieving symptoms of these diseases and provides only a temporary effect for the duration of drug action. The diseases themselves continue to exist in the organisms of the ill. Suffice it to stop taking the drugs as the symptom complex of systemic diseases immediately recurs.
On the basis of a new approach to the etiology and pathogenesis of systemic pathologies, by applying the theory of the pathocomplex process, we offer a radical method of treatment that is capable of completely eliminating the source of these diseases found in the blood.
However, it is necessary to note that having removed the origin of the disease, the body’s dependence upon the use of exogenous corticosteroids that are generally used in the current medicine for the treatment of systemic diseases remains. According to the principle of feedback, long term usage of hormonal preparations triggers disorganization of endocrine control function of hypophysis that changes interrelation between them. As a result of this, the other endocrine glands function taking into account the presence of excessive exogenous corticosteroids in the blood plasma giving rise to a dysfunction, basically in the form of hypofunction of these glands. Due to long-term use of exogenous hormones, the organs that synthesize them, which in this case are the adrenal glands, can atrophy. Consequently, synthesis of autologous hormones decreases or completely stops which then affects the future lives of former patients with systemic pathologies.
The systemic diseases that are currently considered to be induced by pathocomplex process are: rheumatism, systemic scleroderma, systemic lupus erythematosus, dermatomyositis, periarteritis nodosa, glomerulonephritis, systemic vasculitis, arachnoiditis, endocarditis, Raynaud’s disease, pathocomplex induced diabetes, autoimmune thyroiditis, autoimmune hemolytic anemia, idiopathic thrombocytopenic purpura, chorea, multiple sclerosis, parkinsonism, Alzheimer’s disease, multiple myeloma, and even chronic lymphocytic leukemia and lymphogranulomatosis (Hodgkin’s disease) along with others.
Multiple sclerosis, parkinsonism, and Alzheimer’s disease
By studying and analyzing the patterns of the pathocomplex process, we came to the conclusion that multiple sclerosis, parkinsonism, and Alzheimer’s disease emerge as a result of an extensive accumulation of pathocomplexes in the vascular system of the brain. The pathocomplex occlusion of the brain vessels immediately arises simultaneous scattered infarction of its tissues with subsequent necrosis and replacement of brain tissue with fibrous niduses, triggering a manifestation of symptoms particular to one disease or another, depending on the topographic characteristics of the lesions.
Treatments of these pathologies performed on patients based on the theory of the pathocomplex process prove that symptoms of cerebral lesion become less pronounced with improved cerebral blood circulation, and in parallel, cerebral performance also increases, memory and intelligence functions recover. By eliminating the origin of systemic diseases, i.e. the pathocomplex process, the process of further blood vessel occlusion and hence, necrosis of cerebral tissues in the field of their blood supply stops, thus suspending the spread of multiple sclerosis and progression of Parkinson’s and Alzheimer’s diseases. New niduses cease to form; however, unfortunately, previously formed niduses cannot be eliminated because they are now scars and so far, reconstructing a scar tissue back to a highly specific brain tissue is yet impossible. It is true that recently formed niduses can still recover once regenerated under the influence of the treatment process that aims to increase blood circulation. Also, once collateral circulation is improved, healthy regions of the brain can partially take over the functions of affected regions. Elimination of the origin of these diseases at the very least fixates the state of the disease; the disease no longer progresses and no longer aggravates by the formation of new lesions and this too, is an important outcome for such patients.
Chronic lymphocytic leukemia and lymphogranulomatosis
While speaking about diseases of pathocomplex origin, it is impossible not to mention two other diseases.
In the current medicine, chronic lymphocytic leukemia and lymphogranulomatosis (Hodgkin’s disease) are considered as oncopathologies of viral origin with salient features of lymphocyte proliferation in peripheral blood, lymph nodes, and bone marrow as well as an expressed immunodeficiency. And since these diseases are attributed to oncopathology, the central element of their treatment, respectively, consists of heavy chemotherapy.
From our point of view, chronic lymphocytic leukemia and lymphogranulomatosis are pathocomplex diseases accompanied by characteristic of them pronounced immune deficiency. In consequence of immune deficiency, lymphoid tissue and lymph nodes, in particular, react to constantly attacking infectious agents, including viruses, which are always brought forward as the originators of all together incurable diseases.
Based on the theory of the pathocomplex process, once confined in pathocomplex networks, B-lymphocytes are incapable of performing their defensive functions and according to the principle of feedback, as emergency measure, they are intensively synthesized in the bone marrow. Enlargement of the spleen and lymph nodes occurs due to the accumulation of lymphocytes in them.
It is exactly owing to the presence of immune deficiency with Hodgkin’s disease that various infections often develop: viral (herpes), fungal (candidiasis and cryptococcal meningitis), protozoal (toxoplasmosis and pneumocystic pneumonia). The Berezovsky-Reed-Sternberg cells that are detected in this disease are most likely the remnants of the pathocomplexes in which lymphocytes acquire large sizes by fusing into solid conglomerates.
As of today, there is no doubt that a more effective method of treating the diseases of the pathocomplex origin cannot be found in any country in the world. The time will come when our method will replace all currently applied methods of systemic pathology treatments. The sooner this happens, the more patients, who are laying their so much hope on the development of new methods for improving their condition, will live to obtain a truly effective care.
Finally, since skeptics find it convenient to brand any new scientific discovery as "folk medicine" to refute it without going to further troubles, we want to emphasize that the theory of the pathocomplex process and the treatment method derived from it have no relation to traditional medicine in any of its forms whatsoever and while they are significantly different from the treatment methods adapted in the current medicine, and are implemented solely within the scope of modern medicamentous medicine and all drugs administered are on the pharmacological market for over 40 years and are registered with heath ministries of virtually all countries around the world.
